Patients with late-onset schizophrenic psychosis are described as more pronounced cognitive deficits in comparison to regular aging, but less extreme than intellectual modifications noticed in early-onset schizophrenia. Late-onset schizophrenia can be a heterogeneous symptom in terms of cognitive dysfunction. Determination of this dose-dependent effect of the Teraligen for various nosological types of conditions in psychiatric training and basic medication. Despite an extremely lengthy and effective history use, analysis work on the study medication Teraligen continues. Currently Teraligen is extensively and earnestly employed by health practitioners of numerous areas within the psychiatry, neurology, pediatrics, gerontology, inner medication, gastroenterology, gynecology, cardiology, endocrinology and other disciplines. The drug is provided in lot of release types Teraligen 5 mg tablets; Teraligen retard 20 mg; Teraligen solution for intravenous shots. Teraligen is characterized by the next psychotropic results anxiolytic (++ – a definite, moderately obvious result Immune adjuvants ); sedative (++); hypnotic (++); antidee other «small» neuroleptics/antipsychotics with a predominantly sedative impact, the medication enables you to correct neuroleptics-prolongs unwanted effects with dominant manifestations by means of anxiety, frustration and insomnia.Anxiety and depressive disorder tend to be characterized with frequent co-occurance. Despair comorbid to panic increases seriousness of primary disorder, aggravates it`s clinical training course, worsens personal functioning of the patients and decreases life high quality, outcomes resistance to treatment and advances the possibility of suicidal attempts. In clients with depressive disorder onset of anxiety condition outcomes enhanced extent of condition and decline in high quality of remission. You can find different viewpoints on nature and phenomenology of comorbidity of anxiety and depressive disorder. There are biological and psychological elements of threat of comorbidity. Some boffins consider comorbid problems become independent and never to effect one another; others pay attention at typical anatomic basis of comorbid problems, which explains manifestation of comorbid disorder. Hierarchical evaluation of medical attributes of comorbid problems prefers nosological approach to understanding of comorbidity, and implicates the need for addition medical entity recognition of transdiagnostic elements. Some authors consider comorbid conditions to be separate form of condition, characterized with special characteristics of syndromes which shows change of one condition into another. Phenomenon of comorbidity can be described as section of idea of illness spread which estimates important role of connection psychic says. Considering medical popular features of comorbid problems, problems of these therapy predicated on ideas of phenomenology of comorbid depressive and anxiety problems tips about avoidance, very early diagnosis and handling of comorbid problems had been elaborated. Psychotherapy (including CBT, which demonstrated large effectiveness) is an essential component of treatment of comorbid depressive and anxiety problems. Psychotherapy is supposed to be correcting personality traits, cognitive mistakes and maladaptive techniques of coping with disorder, which support the comorbidity.The article provides information from the circumstances of good use and effectiveness of botulinum toxin arrangements, oral muscle mass relaxants, discerning serotonin reuptake inhibitors, acetylcholinesterase inhibitors and a glutamatergic transmission modulator in post-stroke neurorehabilitation, and provides tips for their particular logical and safe usage. The medical effectiveness of Mexidol, which has a polymodal effect on a wide range of post-stroke disorders, particularly in lasting sequential treatment, is talked about. A complex utilization of post-stroke rehabilitation practices utilizing the dedication of specific techniques in line with the Ziprasidone manufacturer clinical picture of the in-patient and also the defined rehab goals is recommended. The inclusion of Mexidol within the complex therapy of patients with stroke consequences for tasks linked to improving engine, affective and cognitive functions and self-care and total well being seems guaranteeing. It is necessary to keep high-quality medical researches to evaluate the pharmaceuticals effectiveness in relation to post-stroke disorders.Orphan diseases have a prevalence ranging one patient per 10.000 populace within the Russian Federation to one per 1500-2000 people in Australian Continent plus the United States Of America. Many orphan diseases induce a severe reduction in standard of living and high death. In this article, we talk about the dilemma of very early analysis in orphan diseases when you look at the Russian Federation, which includes lagged behind global trends towards improved recognition and treatment of orphan diseases. We identify the necessity for enhanced focus at the degree of nationwide health, while speaking about relevant dilemmas due to the intercontinental knowledge. We examine national and local health programs and medical techniques of Australia, Germany, Denmark, Asia, Norway, Slovenia, UK, as well as the usa, with a focus on assessment and diagnosis of orphan infection.